Synthetic brain cells that store 'memories' are possible, new model reveals

Synthetic brain cells that store 'memories' are possible, new model reveals By Qatar Day - August 08, 2021

Synthetic brain cells that store 'memories' are possible

Scientists have created key parts of synthetic brain cells that can hold cellular "memories" for milliseconds. The achievement could one day lead to computers that work like the human brain.

These parts, which were used to model an artificial brain cell, use charged particles called ions to produce an electrical signal, in the same way that information gets transferred between neurons in your brain. 

Current computers can do incredible things, but this processing power comes at a high energy cost. In contrast, the human brain is remarkably efficient, using roughly the energy contained in two bananas to do an entire day's work. While the reasons for this efficiency aren't entirely clear, scientists have reasoned that if they could make a computer more like the human brain, it would require way less energy. One way that scientists try to replicate the brain's biological machinery is by utilizing the power of ions, the charged particles that the brain relies on to produce electricity. 

In the new study, published in the journal Science on Aug. 6, researchers at the Centre national de la recherche scientifique in Paris, France created a computer model of artificial neurons that could produce the same sort of electrical signals neurons use to transfer information in the brain; by sending ions through thin channels of water to mimic real ion channels, the researchers could produce these electrical spikes. And now, they have even created a physical model incorporating these channels as part of unpublished, ongoing research. 

"To my knowledge, it's the first time that people [have done] this with ions," said study co-author Lydéric Bocquet, a physicist at the École Normale Supérieure.

At a finer level, the researchers created a system that mimics the process of generating action potentials —spikes in electrical activity generated by neurons that are the basis of brain activity. To generate an action potential, a neuron starts to let in more positive ions, which are attracted to the negative ions inside of the cell. The electrical potential, or voltage across the cell membrane, causes doorways on the cell called voltage-gated ion channels to open, raising the charge even more before the cell reaches a peak and returns to normal a few milliseconds later. The signal is then transmitted to other cells, enabling information to travel in the brain.

To mimic voltage-gated ion channels, the researchers modeled a thin layer of water between sheets of graphene, which are extremely thin sheets of carbon. The water layers in the simulations were one, two, or three  molecules in depth, which the researchers characterized as a quasi-two-dimension slit. Bocquet said that the researchers wanted to use this two-dimensional environment because particles tend to react much more strongly in two dimensions than in three, and they exhibit different properties in two dimensions, which the researchers thought might be useful for their experiment. 

"In physics, two dimensions is very weird," said Bocquet. "So you expect new things to occur."

Testing out the model in a computer simulation, the researchers found that when they applied an electric field to the channel, the ions in the water formed worm-like structures. As the team applied a greater electric field in the simulation, these structures would break up slowly enough to leave behind a "memory," or a hint of the elongated configuration. 

When the researchers ran a simulation linking two channels and other components to mimic the behavior of a neuron, they found the model could generate spikes in electrical activity like action potentials, and that it "remembered" consistent properties in two different states — one where ions conducted more electricity and one where they conducted less. In this simulation, the "memory" of the previous state of the ions lasted a few milliseconds, around the same time as it takes real neurons to produce an action potential and return to a resting state. This is quite a long time for ions, which usually operate on timescales of nanoseconds or less. In a real neuron, an action potential equates to a cellular memory in the neuron; our brains use the opening and closing of ion channels to create this kind of memory.

"We have similar memory in the end, but the reason for the phenomenon is very different," Bocquet said.

Making a 'memory'

The new model is a version of an electronic component called a memristor, or a memory resistor, which has the unique property of retaining information from its history. But existing memristors don't use liquid, as the brain does. 

"The typical memristors that I work with, and other people in the literature work with, are solid-state memristors," said Gina Adam, an assistant professor of electrical and computer engineering at George Washington University, who was not involved in the study. This new research on creating fluid memristors is "very promising and very intriguing," Adam added.

She also said that while practical brain-like computers are likely a long way away, this research could also help scientists better understand how the brain processes information and develop new theories of brain-like computing. 

Since conducting this research with computer simulations, Bocquet says he and collaborators at the University of Manchester in the U.K. have brought their theory to life, using it to create an artificial synapse, the part of a neuron that passes on electric signals, and they have started performing experiments with it.

"It's exciting because it's a playground now," Bocquet said. "We can explore these things actively."

By Qatar Day - August 08, 2021

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